Preparation of a biodegradable matrix through polyion complex formation by mixing polylactide-based microspheres having oppositely charged surfaces

被引：5

作者：

Arimura, H ^{[1
]}

Ohya, Y

Ouchi, T

Yamada, H

机构：

[1] Kansai Univ, Fac Engn, Suita, Osaka 5648680, Japan

[2] Kansai Univ, High Technol Res Ctr, Suita, Osaka 5648680, Japan

[3] Kuraray Co Ltd, Kurashiki, Okayama 7108622, Japan

来源：

JOURNAL OF COLLOID AND INTERFACE SCIENCE | 2004年 / 270卷 / 02期

基金：

日本学术振兴会;

关键词：

polylactide; microsphere; charged surface; polyion complex; biodegradable; peptide; ionic strength; bioabsorbable; bioadhesive; biocompatible;

D O I：

10.1016/j.jcis.2003.10.010

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The aggregation of polyions into microsphere (MS) complexes was studied as a preparative method for the construction of a biodegradable matrix. Aqueous suspensions of polylactide (PLA)-based MSs with positively and negatively charged surfaces, MS(K-3(4+)-PLA) and MS(E-3(4-)-PLA), respectively, immediately formed aggregates when mixed. The effects of the stoichiometry of the charged groups on the surfaces of the MSs and the ionic strength of the medium on aggregate formation, as well as the degradation behavior of the polyion complex (PIC) matrix over time, were investigated. (C) 2003 Elsevier Inc. All rights reserved.

引用

页码：299 / 303

页数：5

共 18 条

[1] Preparation of polylactide microspheres having positively or negatively charged surfaces [J].