Genomic regions linked to alcohol consumption in the Framingham Heart Study

被引：44

作者：

Bergen, AW ^{[1
]}

Yang, XHR

Bai, Y

Beerman, MB

Goldstein, AM

Goldin, LR

机构：

[1] NCI, Core Genotyping Facil, Ctr Adv Technol, NIH,DHHS, Gaithersburg, MD USA

[2] NCI, Genet Epidemiol Branch, Div Canc Epidemiol & Genet, NIH,DHHS, Gaithersburg, MD USA

[3] SAIC Frederick Inc, Core Genotyping Facil, Frederick, MD USA

来源：

BMC GENETICS | 2003年 / 4卷 / Suppl 1期

关键词：

D O I：

10.1186/1471-2156-4-S1-S101

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Background: Pedigree, demographic, square-root transformed maximum alcohol (SRMAXAPD) and maximum cigarette (MAXCPD) consumption, and genome-wide scan data from the Framingham Heart Study (FHS) were used to investigate genetic factors that may affect alcohol and cigarette consumption in this population-based sample. Results: A significant sister: sister correlation greater than spouse correlation was observed for MAXCPD only. Single-point sib-pair regression analysis provided nominal evidence for linkage of loci to both SRMAXAPD and MAXCPD consumption traits, with more significant evidence of linkage to SRMAXAPD than to MAXCPD. One genomic region, chr9q21.11, exhibits significant multi-point sib-pair regression to SRMAXAPD. Conclusion: SRMAXAPD exhibits greater evidence for genetic linkage than does MAXCPD in the FHS sample. Four regions of the genome exhibiting nominal evidence for linkage to SRMAXAPD in the FHS sample correspond to regions of the genome previously identified as linked to alcoholism or related traits in the family data set ascertained on individuals affected with alcohol dependence known as COGA.

引用

页数：6

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