Effects of ultrasound-assisted compaction on Ketoprofen Eudragit® S100 mixtures

Ketoprofen alone and in binary mixtures with Eudragit(R) S100 was compacted by an ultrasound-assisted (US) tableting machine at an energy ranging from 50 to 400 J. The final material was analysed by TLC and HPLC: no decomposition product of the active agent was found. IR spectra and HSM revealed the absence of any interaction between the two components. Thermal analysis (DSC) evidenced that ketoprofen inside the mixtures was transformed into an amorphous state, documented by the decreasing of the Delta H-fus as the Eudragit(R)/ketoprofen ratio increases and as US energy increases. While pure ketoprofen recovers its crystalline state quickly after the US treatment, the presence of Eudragit(R) was found to slow down or possibly to prevent the regeneration of the crystallinity. (C) 1999 Elsevier Science B.V. All rights reserved.