IL-9-and mast cell-mediated intestinal permeability predisposes to oral antigen hypersensitivity

被引：224

作者：

Forbes, Elizabeth E. ^{[1
,2
]}

Groschwitz, Katherine ^{[1
,2
,3
]}

Abonia, J. Pablo ^{[1
]}

Brandt, Eric B. ^{[1
]}

Cohen, Elizabeth ^{[1
]}

Blanchard, Carine ^{[1
]}

Ahrens, Richard ^{[1
]}

Seidu, Luqman ^{[1
]}

McKenzie, Andrew ^{[8
]}

Strait, Richard ^{[2
,4
]}

Finkelman, Fred D. ^{[2
,9
]}

Foster, Paul S. ^{[5
,7
]}

Matthaei, Klaus I. ^{[6
]}

Rothenberg, Marc E. ^{[1
]}

Hogan, Simon P. ^{[1
]}

机构：

[1] Univ Cincinnati, Coll Med, Dept Pediat,Div Allergy & Immunol, Cincinnati Childrens Hosp,Med Ctr, Cincinnati, OH 45267 USA

[2] Univ Cincinnati, Coll Med, Dept Pediat,Div Immunobiol, Cincinnati Childrens Hosp,Med Ctr, Cincinnati, OH 45267 USA

[3] Univ Cincinnati, Coll Med, Dept Pediat,Grad Program Immunobiol, Cincinnati Childrens Hosp,Med Ctr, Cincinnati, OH 45267 USA

[4] Univ Cincinnati, Coll Med, Dept Pediat,Div Emergency Med, Cincinnati Childrens Hosp,Med Ctr, Cincinnati, OH 45267 USA

[5] John Curtin Sch Med Res, Div Mol Sci, Allergy & Inflammat Res Grp, Canberra, ACT 2601, Australia

[6] John Curtin Sch Med Res, Div Mol Sci, Gene Targeting Grp, Canberra, ACT 2601, Australia

[7] Univ Newcastle, Sch Biomed Sci, Asthma Allergy & Inflammat Res Ctr, Newcastle, NSW 2308, Australia

[8] MRC, Mol Biol Lab, Cambridge CB2 2QH, England

[9] Cincinnati Vet Affair Med Ctr, Dept Med, Cincinnati, OH 45220 USA

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2008年 / 205卷 / 04期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1084/jem.20071046

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Previous mouse and clinical studies demonstrate a link between Th2 intestinal inflammation and induction of the effector phase of food allergy. However, the mechanism by which sensitization and mast cell responses occurs is largely unknown. We demonstrate that interleukin (IL)-9 has an important role in this process. IL-9-deficient mice fail to develop experimental oral antigen-induced intestinal anaphylaxis, and intestinal IL-9 overexpression induces an intestinal anaphylaxis phenotype ( intestinal mastocytosis, intestinal permeability, and intravascular leakage). In addition, intestinal IL-9 overexpression predisposes to oral antigen sensitization, which requires mast cells and increased intestinal permeability. These observations demonstrate a central role for IL-9 and mast cells in experimental intestinal permeability in oral antigen sensitization and suggest that IL-9-mediated mast cell responses have an important role in food allergy.

引用

页码：897 / 913

页数：17

共 92 条

[1] IL-9 is a susceptibility factor in leishmania major infection by promoting detrimental Th2/type 2 responses [J].