Grape polyphenols protect neurodegenerative changes induced by chronic ethanol administration

被引:45
作者
Sun, GY
Xia, JM
Draczynska-Lusiak, B
Simonyi, A
Sun, AY
机构
[1] Univ Missouri, Dept Biochem, Columbia, MO 65212 USA
[2] Univ Missouri, Dept Pharmacol, Columbia, MO 65212 USA
关键词
antioxidants; chronic alcohol consumption; dopamine uptake; grape polyphenols; Na; K-ATPase; neurodegeneration; neuroprotection; synaptic membranes;
D O I
10.1097/00001756-199901180-00018
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
INCREASED oxidative stress in the brain due to chronic ethanol consumption is known to result in a number of neurodegenerative changes. This study was designed to test whether dietary supplementation of grape polyphenols (GP) can offer protection to the neurodegenerative changes resulting from chronic ethanol consumption. Sprague-Dawley rats were fed a Leiber-DeCarli liquid diet with ethanol or isocaloric amount of maltose, and with or without GP for 2 months. Chronic ethanol caused significant decreases in synaptosomal Na,KATPase (20.5%) and dopamine uptake (22.8%) activities compared with pair-fed controls. Although GP alone did not alter activities of these membrane-bound proteins, GP supplementation was able to completely protect the decrease in synaptic protein function elicited by chronic ethanol consumption. (C) 1999 Lippincott Williams & Wilkins.
引用
收藏
页码:93 / 96
页数:4
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