Molecular implementation and physiological roles for histone H3 lysine 4 (H3K4) methylation

被引：391

作者：

Shilatifard, Ali ^{[1
]}

机构：

[1] Stowers Inst Med Res, Kansas City, MO 64110 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 2008年 / 20卷 / 03期

关键词：

D O I：

10.1016/j.ceb.2008.03.019

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Chromosomal surfaces are ornamented with a variety of post-translational modifications of histones, which are required for the regulation of many of the DNA-templated processes. Such histone modifications include acetylation, sumoylation, phosphorylation, ubiquitination, and methylation. Histone modifications can either function by disrupting chromosomal contacts or by regulating non-histone protein interactions with chromatin. In this review, recent findings will be discussed regarding the regulation of the implementation and physiological significance for one such histone modification, histone H3 lysine 4 (H3K4) methylation by the yeast COMPASS and mammalian COMPASS-like complexes.

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页码：341 / 348

页数：8

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