Susceptibility of pigs and chickens to SARS coronavirus

被引：65

作者：

Weingartl, HM ^{[1
]}

Copps, J ^{[1
]}

Drebot, MA ^{[1
]}

Marszal, P ^{[1
]}

Smith, G ^{[1
]}

Gren, J ^{[1
]}

Andonova, M ^{[1
]}

Pasick, J ^{[1
]}

Kitching, P ^{[1
]}

Czub, M ^{[1
]}

机构：

[1] Canadian Sci Ctr Human & Anim Hlth, Winnipeg, MB, Canada

来源：

EMERGING INFECTIOUS DISEASES | 2004年 / 10卷 / 02期

关键词：

D O I：

10.3201/eid1002.030677

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

An outbreak of severe acute respiratory syndrome (SARS) in humans, associated with a new coronavirus, was reported in Southeast Asia, Europe, and North America in early 2003. To address speculations that the virus originated in domesticated animals, or that domestic species were susceptible to the virus, we inoculated 6-week-old pigs and chickens intravenously, intranasally, ocularly, and orally with 106 PFU of SARS-associated coronavirus (SARS-CoV). Clinical signs did not develop in any animal, nor were gross pathologic changes evident on postmortem examinations. Attempts at virus isolation were unsuccessful; however, viral RNA was detected by reverse transcriptase-polymerase chain reaction in blood of both species during the first week after inoculation, and in chicken organs at 2 weeks after inoculation. Virus-neutralizing antibodies developed in the pigs. Our results indicate that these animals do not play a role as amplifying hosts for SARS-CoV.

引用

页码：179 / 184

页数：6

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