Atomoxetine Treatment of ADHD in Children With Comorbid Tourette Syndrome

被引：63

作者：

Spencer, Thomas J. ^{[1
]}

Sallee, F. Randy

Gilbert, Donald L. ^{[2
]}

Dunn, David W. ^{[3
,4
]}

McCracken, James T. ^{[5
]}

Coffey, Barbara J. ^{[6
]}

Budman, Cathy L. ^{[7
]}

Ricardi, Randall K.

Leonard, Henrietta L. ^{[8
]}

Allen, Albert J.

Milton, Denai R.

Feldman, Peter D.

Kelsey, Douglas K.

Geller, Daniel A. ^{[9
]}

Linder, Steven L. ^{[10
]}

Lewis, Donald W.

Winner, Paul K.

Kurlan, Roger M. ^{[11
]}

Mintz, Mark

机构：

[1] Massachusetts Gen Hosp, Clin & Res Program Pediat Psychopharmacol, Boston, MA 02114 USA

[2] Cincinnati Childrens Hosp, Med Ctr, Movement Disorders & Tourette Syndrome Clin, Cincinnati, OH USA

[3] Indiana Univ, Sch Med, Dept Psychiat, Bloomington, IN 47405 USA

[4] Indiana Univ, Sch Med, Dept Neurol, Bloomington, IN 47405 USA

[5] Univ Calif Los Angeles, Inst Neuropsychiat, Joseph Campbell Div Child & Adolescent Psychiat, Los Angeles, CA 90024 USA

[6] NYU, Ctr Child Study, Tourette & Tic Inst, New York, NY 10003 USA

[7] N Shore Univ Hosp, Long Isl Jewish Hlth Syst, Manhasset, NY USA

[8] Brown Univ, Rhode Isl Hosp, Providence, RI 02912 USA

[9] Harvard Univ, Sch Med, McLean Hosp, Dept Psychiat, Cambridge, MA 02138 USA

[10] Dallas Pediat Neurol Associates, Dallas, TX USA

[11] Univ Rochester, Sch Med & Dent, Rochester, NY 14627 USA

来源：

JOURNAL OF ATTENTION DISORDERS | 2008年 / 11卷 / 04期

关键词：

atomoxetine; ADHD; tic disorders; Tourette syndrome;

D O I：

10.1177/1087054707306109

中图分类号：

B844 [发展心理学（人类心理学）];

学科分类号：

040202 ;

摘要：

Objective: This study examines changes in severity of tics and ADHD during atomoxetine treatment in ADHD patients with Tourette syndrome (TS). Method: Subjects (7-17 years old) with ADHD (Diagnostic and Statistical Manual of Mental Disorders, DSM-IV) and TS were randomly assigned to double-blind treatment with placebo (n = 56) or atomoxetine (0.5-1.5 mg/kg/day, n = 61) for approximately 18 weeks. Results: Atomoxetine subjects showed significantly greater improvement on ADHD symptom measures. Treatment was also associated with significantly greater reduction of tic severity on two of three measures. Significant increases were seen in mean pulse rate and rates of treatment-emergent nausea, decreased appetite, and decreased body weight. No other clinically relevant treatment differences were observed in any other vital sign, adverse event, laboratory parameter, or electrocardiographic measure. Conclusion: Atomoxetine is efficacious for treatment of ADHD and its use appears well tolerated in ADHD patients with comorbid TS. (J. of Att. Dis. 2008; 11(4) 470-481)

引用

页码：470 / 481

页数：12

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