Peripheral blood CD38 expression predicts survival in B-cell chronic lymphocytic leukemia

被引：48

作者：

Morabito, F ^{[1
]}

Mangiola, M

Oliva, B

Stelitano, C

Callea, V

Deaglio, S

Iacopino, P

Brugiatelli, M

Malavasi, F

机构：

[1] Azienda Osped Bianchi Melacrino Morelli, Dipartimento Ematol, Ctr Trapianti Midollo Osseo, I-89100 Reggio Di Calabria, Italy

[2] Azienda Osped Bianchi Melacrino Morelli, Dipartimento Ematol, Div Ematol, I-89100 Reggio Di Calabria, Italy

[3] Azienda Osped Bianchi Melacrino Morelli, Dipartimento Ematol, Ctr Microcitemie, I-89100 Reggio Di Calabria, Italy

[4] Univ Turin, Dipartimento Biol Genet & Biochim, Turin, Italy

来源：

LEUKEMIA RESEARCH | 2001年 / 25卷 / 11期

关键词：

B-CLL; CD38; survival; prognosis; monoclonal antibody;

D O I：

10.1016/S0145-2126(01)00049-2

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

CD38 expression was investigated in 161 untreated patients with B-cell chronic lymphocytic leukemia (B-CLL). A score system, devised ad hoc by integrating the percentage and the mean fluorescence intensity (MFI) values of CD38(+) cells, indicated that B-CLL patients with a CD38 score less than or equal to 3 are characterized by a significantly longer survival compared to those with a CD38 score > 3 (P = 0.0026). Thirty-seven percent of patients with a CD38 score less than or equal to 3 and 58% of those with a score > 3 were dead at 10 years. Multivariate analysis indicates that only the CD38 score successfully predicts survival (P = 0.0028), with an estimated 3.8-fold greater risk of death for those cases with CD38 score > 3. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：927 / 932

页数：6

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