The half-life of RAG-1 protein in precursor B cells is increased in the absence of RAG-2 expression

被引：23

作者：

Grawunder, U

Schatz, DG

Leu, TMJ

Rolink, A

Melchers, F

机构：

[1] BASEL INST IMMUNOL,CH-4005 BASEL,SWITZERLAND

[2] YALE UNIV,SCH MED,IMMUNOBIOL SECT,NEW HAVEN,CT 06520

[3] YALE UNIV,SCH MED,HOWARD HUGHES MED INST,NEW HAVEN,CT 06510

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 1996年 / 183卷 / 04期

关键词：

D O I：

10.1084/jem.183.4.1731

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Site-specific recombination of immunoglobulin and T cell receptor gene segments in B and T lymphocytes is dependent on the expression of two recombination activation genes, Rag-1 and Rag-2. Here, we show that RAG-1 protein turnover in pre-B cells depends on the expression of RAG-2. The apparent half-life of RAG-1 protein is increased when RAG-2 is not expressed in differentiating pre-B cells.

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页码：1731 / 1737

页数：7

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