Stress-limiting effect of dehydroepiandrosterone sulfate and its mechanism

被引：7

作者：

Obut, TA ^{[1
]}

Ovsyukova, MV ^{[1
]}

Cherkasova, OP ^{[1
]}

机构：

[1] Russian Acad Med Sci, Siberian Div, Inst Physiol, Novosibirsk, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2003年 / 135卷 / 03期

关键词：

dehydroepiandrosterone sulfate; stress reactivity; mu-opioid receptors;

D O I：

10.1023/A:1024168510925

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Dehydroepiandrosterone sulfate prevented the increase in corticosterone level in rats induced by repeated exposure to stress. The mu-opioid receptor blocker naltrexone administered in a dose of 0.1 mg/kg 20 min before treatment with dehydroepiandrosterone sulfate abolished the effect of this agent. Dehydroepiandrosterone sulfate and naltrexone had no effect on rats after acute stress.

引用

页码：231 / 233

页数：3

共 14 条

[1] THE EFFECT OF NALOXONE ADMINISTRATION ON THE SECRETION OF CORTICOTROPIN-RELEASING HORMONE, ARGININE-VASOPRESSIN, AND ADRENOCORTICOTROPIN IN UNPERTURBED HORSES [J].

ALEXANDER, SL ;

IRVINE, CHG .

ENDOCRINOLOGY, 1995, 136 (11) :5139-5147

[2]

Baulieu EE, 1997, RECENT PROG HORM RES, V52, P1

[3] EFFECTS OF SELECTIVE OPIOID-RECEPTOR BLOCKADE ON THE HYPOTHALAMO-PITUITARY-ADRENOCORTICAL RESPONSES TO SURGICAL TRAUMA IN THE RAT [J].

COVER, PO ;

BUCKINGHAM, JC .

JOURNAL OF ENDOCRINOLOGY, 1989, 121 (02) :213-220

[4] OPIOID PEPTIDE AND ALPHA-ADRENOCEPTOR PATHWAYS IN THE REGULATION OF THE PITUITARY-ADRENAL AXIS IN MAN [J].

DELITALA, G ;

TRAINER, PJ ;

OLIVA, O ;

FANCIULLI, G ;

GROSSMAN, AB .

JOURNAL OF ENDOCRINOLOGY, 1994, 141 (01) :163-168

[5] Role of endogenous opioid system in the regulation of the stress response [J].

Drolet, G ;

Dumont, EC ;

Gosselin, I ;

Kinkead, R ;

Laforest, S ;

Trottier, JF .

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 2001, 25 (04) :729-741

[6] Effect of chronic psychogenic stress exposure on enkephalin neuronal activity and expression in the rat hypothalamic paraventricular nucleus [J].

Dumont, EC ;

Kinkead, R ;

Trottier, JF ;

Gosselin, I ;

Drolet, G .

JOURNAL OF NEUROCHEMISTRY, 2000, 75 (05) :2200-2211

[7] CHRONIC STRESS INCREASES THE OPIOID-MEDIATED INHIBITION OF THE PITUITARY-ADRENOCORTICAL RESPONSE TO ACUTE STRESS IN PIGS [J].

JANSSENS, CJJG ;

HELMOND, FA ;

LOYENS, LWS ;

SCHOUTEN, WGP ;

WIEGANT, VM .

ENDOCRINOLOGY, 1995, 136 (04) :1468-1473

[8]

LISHMANOV YB, 1994, OPIOID NEUROPEPTIDES

[9]

Obut T. A., 1994, Byulleten' Eksperimental'noi Biologii i Meditsiny, V118, P8

[10]

OBUT TA, 1998, VESTN ROS AKAD MED N, V19, P18

← 1 2 →