CD34+-enriched donor lymphocyte infusions in a case of pure red cell aplasia and late graft failure after major ABO-incompatible bone marrow transplantation

被引：20

作者：

Selleri, C ^{[1
]}

Raiola, A ^{[1
]}

De Rosa, G ^{[1
]}

Luciano, L ^{[1
]}

Pezzullo, L ^{[1
]}

Picardi, M ^{[1
]}

Rotoli, B ^{[1
]}

机构：

[1] Univ Naples Federico II, Div Hematol, Sch Med, I-80131 Naples, Italy

来源：

BONE MARROW TRANSPLANTATION | 1998年 / 22卷 / 06期

关键词：

PRCA; graft failure; DLI; CD34(+) cells;

D O I：

10.1038/sj.bmt.1701384

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

A variety of immunohematological complications may occur after ABO-incompatible BMT, We report a CML patient (blood group O) who received a BMT from an HLA-identical sibling (blood group AB). The transplant was followed by normal myeloid and megakaryocytic engraftment, but erythroblastopenia persisted for more than 200 days after BMT, By bone marrow culture studies, a complement-dependent serum inhibitor of hemopoiesis was detected, suggesting immunological inhibition of erythropoiesis. The patient was resistant to a number of treatments such as intravenous gammaglobulins, prednisolone and high-dose erythropoietin. Full engraftment with normal blood counts and marrow cellularity was achieved after two dose-escalating CD34(+)-enriched donor lymphocyte infusions (DLI), This experience suggests that CD34(+)-enriched DLI may be an effective treatment for patients,vith delayed engraftment or late graft failure due to major ABO-incompatibility.

引用

页码：605 / 607

页数：3

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