Interaction between platinum complexes and a methionine motif found in copper transport proteins

被引：85

作者：

Arnesano, Fabio ^{[1
]}

Scintilla, Simone ^{[1
]}

Natile, Giovanni ^{[1
]}

机构：

[1] Univ Bari, Dipartimento Farmacochim, I-70125 Bari, Italy

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 47期

关键词：

antitumor agents; copper; methionine; NMR spectroscopy; platinum;

D O I：

10.1002/anie.200703271

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Going to the Mets: The uptake of Pt anticancer drugs also involves the Cu transporter Ctr1, which is located on the plasma membrane and contains functionally essential methionine-rich motifs. The methionine-rich peptide Mets7 reacts readily with PtII species. A striking difference between cis- and trans-[PtCl2(NH3)2] is that, upon reaction with Mets7, only the latter retains its N-donor ligands. Delivery of undegraded Pt drug to intracellular organelles by vesicle trafficking is hypothesized. (Figure Presented) © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

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收藏

页码：9062 / 9064

页数：3

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