Multilocus sequence typing directly on DNA from clinical samples and a cultured isolate to investigate linked fatal pneumococcal disease in residents of a shelter for homeless men

被引：15

作者：

Birtles, A

McCarthy, N

Sheppard, CL

Rutter, H

Guiver, M

Haworth, E

George, RC

机构：

[1] Cent Publ Hlth Lab, Resp & Syst Infect Lab, Hlth Protect Agcy, London NW9 5HT, England

[2] NW Reg Lab, Hlth Protect Agcy, South East Reg, Manchester, Lancs, England

[3] NW Reg Lab, SE Publ hlth Observ, Manchester, Lancs, England

[4] NW Reg Lab, Hlth Protect Agcy, Meningococcal Reference Unit, Manchester, Lancs, England

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2005年 / 43卷 / 04期

关键词：

D O I：

10.1128/JCM.43.4.2004-2008.2005

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Two apparently linked fatal cases of pneumococcal meningitis were investigated. Pneumolysin PCR performed on blood and cerebrospinal fluid was positive in a culture-negative case. A second case yielded Streptococcus pneumoniae from blood culture. Multilocus sequence typing performed on DNA extracted from case 1 (specimens) and case 2 (isolate) revealed identical sequence types (ST53) substantiating the link between them.

引用

页码：2004 / 2008

页数：5

共 22 条

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