Development of vaccines for prevention of Ebola virus infection

被引：23

作者：

Ye, Ling ^{[1
]}

Yang, Chinglai ^{[1
]}

机构：

[1] Emory Univ, Sch Med, Dept Microbiol & Immunol, Atlanta, GA 30322 USA

来源：

MICROBES AND INFECTION | 2015年 / 17卷 / 02期

关键词：

Ebola; Vaccine; Immune response; Animal model; PROTECTS NONHUMAN-PRIMATES; EQUINE ENCEPHALITIS-VIRUS; RESPIRATORY-TRACT IMMUNIZATION; MARMOSET CALLITHRIX-JACCHUS; T-CELL RESPONSES; HEMORRHAGIC-FEVER; MARBURG VIRUS; GUINEA-PIGS; NEUTRALIZING ANTIBODIES; MEDIATED PROTECTION;

D O I：

10.1016/j.micinf.2014.12.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Ebola virus infection causes severe hemorrhagic fevers with high fatality rates up to 90% in humans, for which no effective treatment is currently available. The ongoing Ebola outbreak in West Africa that has caused over 14,000 human infections and over 5000 deaths underscores its serious threat to the public health. While licensed vaccines against Ebola virus infection are still not available, a number of vaccine approaches have been developed and shown to protect against lethal Ebola virus infection in animal models. This review aims to summarize the advancement of different strategies for Ebola vaccine development with a focus on the discussion of their protective efficacies and possible limitations. In addition, the development of animal models for efficacy evaluation of Ebola vaccines and the mechanism of immune protection against Ebola virus infection are also discussed. (C) 2015 Published by Elsevier Masson SAS on behalf of Institut Pasteur.

引用

页码：98 / 108

页数：11

共 102 条

[1] Ebola virus antibody prevalence in dogs and human risk [J].

Allela, L ;

Bourry, O ;

Pouillot, R ;

Délicat, A ;

Yaba, P ;

Kumulungui, B ;

Rouquet, P ;

Gonzalez, JP ;

Leroy, EM .

EMERGING INFECTIOUS DISEASES, 2005, 11 (03) :385-390

[2] Discovery of Swine as a Host for the Reston ebolavirus [J].

Barrette, Roger W. ;

Metwally, Samia A. ;

Rowland, Jessica M. ;

Xu, Lizhe ;

Zaki, Sherif R. ;

Nichol, Stuart T. ;

Rollin, Pierre E. ;

Towner, Jonathan S. ;

Shieh, Wun-Ju ;

Batten, Brigid ;

Sealy, Tara K. ;

Carrillo, Consuelo ;

Moran, Karen E. ;

Bracht, Alexa J. ;

Mayr, Gregory A. ;

Sirios-Cruz, Magdalena ;

Catbagan, Davinio P. ;

Lautner, Elizabeth A. ;

Ksiazek, Thomas G. ;

White, William R. ;

McIntosh, Michael T. .

SCIENCE, 2009, 325 (5937) :204-206

[3] Disease modeling for Ebola and Marburg viruses [J].

Bente, Dennis ;

Gren, Jason ;

Strong, James E. ;

Feldmann, Heinz .

DISEASE MODELS & MECHANISMS, 2009, 2 (1-2) :12-17

[4] Antibody Quality and Protection from Lethal Ebola Virus Challenge in Nonhuman Primates Immunized with Rabies Virus Based Bivalent Vaccine [J].

Blaney, Joseph E. ;

Marzi, Andrea ;

Willet, Mallory ;

Papaneri, Amy B. ;

Wirblich, Christoph ;

Feldmann, Friederike ;

Holbrook, Michael ;

Jahrling, Peter ;

Feldmann, Heinz ;

Schnell, Matthias J. .

PLOS PATHOGENS, 2013, 9 (05)

[5] Inactivated or Live-Attenuated Bivalent Vaccines That Confer Protection against Rabies and Ebola Viruses [J].

Blaney, Joseph E. ;

Wirblich, Christoph ;

Papaneri, Amy B. ;

Johnson, Reed F. ;

Myers, Carey J. ;

Juelich, Terry L. ;

Holbrook, Michael R. ;

Freiberg, Alexander N. ;

Bernbaum, John G. ;

Jahrling, Peter B. ;

Paragas, Jason ;

Schnell, Matthias J. .

JOURNAL OF VIROLOGY, 2011, 85 (20) :10605-10616

[6]

BOWEN ETW, 1977, LANCET, V1, P571

[7] Haematological, biochemical and coagulation changes in mice, guinea-pigs and monkeys infected with a mouse-adapted variant of Ebola Zaire virus [J].

Bray, M ;

Hatfill, S ;

Hensley, L ;

Huggins, JW .

JOURNAL OF COMPARATIVE PATHOLOGY, 2001, 125 (04) :243-253

[8] A mouse model for evaluation of prophylaxis and therapy of Ebola hemorrhagic fever [J].

Bray, M ;

Davis, K ;

Geisbert, T ;

Schmaljohn, C ;

Huggins, J .

JOURNAL OF INFECTIOUS DISEASES, 1999, 179 :S248-S258

[9] The role of the Type I interferon response in the resistance of mice to filovirus infection [J].

Bray, M .

JOURNAL OF GENERAL VIROLOGY, 2001, 82 :1365-1373

[10] A single intranasal inoculation with a paramyxovirus-vectored vaccine protects guinea pigs against a lethal-dose Ebola virus challenge [J].

Bukreyev, A ;

Yang, LJ ;

Zaki, SR ;

Shieh, WJ ;

Rollin, PE ;

Murphy, BR ;

Collins, PL ;

Sanchez, A .

JOURNAL OF VIROLOGY, 2006, 80 (05) :2267-2279

← 1 2 3 4 5 6 7 8 9 10 →