Acute basilar artery occlusion: Endovascular Interventions versus Standard Medical Treatment (BEST) TrialDesign and protocol for a randomized, controlled, multicenter study

被引：54

作者：

Liu, Xinfeng ^{[1
]}

Xu, Gelin ^{[1
]}

Liu, Yuxiu ^{[2
]}

Zhu, Wusheng ^{[1
]}

Ma, Minmin ^{[1
]}

Xiong, Yunyun ^{[1
]}

Zi, Wenjie ^{[1
]}

Dai, Qiliang ^{[1
]}

Leung, Thomas ^{[3
]}

Yan, Bernard ^{[4
]}

Davis, Stephen ^{[4
]}

Liebeskind, David S. ^{[5
,6
]}

Pereira, Vitor M. ^{[7
]}

Nogueira, Raul G. ^{[8
]}

机构：

[1] Nanjing Univ, Jinling Hosp, Dept Neurol, Sch Med, Nanjing, Jiangsu, Peoples R China

[2] Jinling Hosp, Dept Med Stat, Nanjing, Jiangsu, Peoples R China

[3] Chinese Univ Hong Kong, Dept Med & Therapeut, Hong Kong, Hong Kong, Peoples R China

[4] Univ Melbourne, Royal Melbourne Hosp, Melbourne Brain Ctr, Parkville, Vic, Australia

[5] Univ Calif Los Angeles, Neurovasc Imaging Res Core, Los Angeles, CA USA

[6] Univ Calif Los Angeles, Dept Neurol, UCLA Stroke Ctr, Los Angeles, CA 90024 USA

[7] Univ Toronto, Toronto Western Hosp, Dept Med Imaging & Surg, Toronto, ON, Canada

[8] Emory Univ, Sch Med, Dept Neurol Neurosurg & Radiol, Atlanta, GA USA

来源：

INTERNATIONAL JOURNAL OF STROKE | 2017年 / 12卷 / 07期

关键词：

Thrombectomy; basilar artery; stroke; endovascular treatment; randomized; ACUTE ISCHEMIC-STROKE; INTRAVENOUS T-PA; INTERNATIONAL-COOPERATION; MECHANICAL THROMBECTOMY; IMAGING SELECTION; CONTROLLED-TRIAL; THROMBOLYSIS; RETRIEVER; ALTEPLASE; PREDICTS;

D O I：

10.1177/1747493017701153

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

Rationale Endovascular treatment plus standard medical therapy is superior to standard medical therapy alone for acute anterior proximal intracranial large artery occlusion strokes. The benefit of endovascular treatment in acute ischemic stroke caused by basilar artery occlusion remains unproven. Aim This study compares the safety and efficacy of endovascular treatment plus standard medical therapy versus standard medical therapy alone in acute ischemic stroke due to basilar artery occlusion. Design The study is a multicenter randomized control trial with blinded outcome assessment. A projected total 344 subjects with acute basilar arterial occlusion within 8h of estimated occlusion time will be enrolled over three years in China. Patients will be assigned to endovascular treatment plus standard medical therapy and standard medical therapy alone group in 1:1 ratio for study centers. Study outcomes The primary outcome measure is a favorable functional outcome, defined as a modified Rankin Score of 0-3 at 90 days. The primary safety measure is mortality at 90 days. Trial registration ClinicalTrials.gov (NCT 02441556). Summary The BEST trial will provide valuable insights into the safety and efficacy of endovascular treatment for acute ischemic stroke patients with basilar artery occlusion.

引用

页码：779 / 785

页数：7

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