TAK bipotent progenitors in the thymus retain the potential to generate dendritic cells

被引：51

作者：

Shen, HQ

Lu, M

Ikawa, T

Masuda, K

Ohmura, K

Minato, N

Katsura, Y

Kawamoto, H

机构：

[1] Kyoto Univ, Fac Med, Dept Immunol & Cell Biol, Lab Lymphocyte Dev,Sakyo Ku, Kyoto 6068501, Japan

[2] RIKEN, Lab Lymphocyte Dev, Res Ctr Allergy & Immunol, Yokohama, Kanagawa, Japan

[3] Kyoto Univ, Grad Sch Biostudies, Dept Immunol & Cell Biol, Kyoto, Japan

[4] Nihon Univ, Sch Med, Div Cell Regenerat, Adv Med Res Ctr, Tokyo, Japan

来源：

JOURNAL OF IMMUNOLOGY | 2003年 / 171卷 / 07期

关键词：

D O I：

10.4049/jimmunol.171.7.3401

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We have previously shown that the earliest thymic progenitors retain the potential to generate T and NK cells and that they lose the bipotentiality to give rise to unipotent T and NK progenitors during the progression of intrathymic developmental stages. The present study examines the ability of these thymic progenitors for generation of dendritic cells (DC) with a new clonal assay that is capable of determining the developmental potential for DC in addition to T cells and NK cells. We found that the large majority of the T/NK bipotential progenitors in the earliest population of fetal thymus was able to generate DC. Although the DC potential is lost with the progression of the differentiation stage, some of the T/NK bipotential progenitors still retain their DC potential even at the CD44(+)CD25(+) stage.

引用

页码：3401 / 3406

页数：6

共 34 条

[1] Generation of CD1(+)RelB(+) dendritic cells and tartrate-resistant acid phosphatase-positive osteoclast-like multinucleated giant cells from human monocytes [J].