HIV-1 infection: fooling the gatekeeper

被引:3
作者
Cullen, BR [1 ]
机构
[1] Duke Univ, Med Ctr, Howard Hughes Med Inst, Durham, NC 27710 USA
[2] Duke Univ, Med Ctr, Dept Mol Genet & Microbiol, Durham, NC 27710 USA
关键词
D O I
10.1038/nm0903-1112
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Why are humans particularly susceptible to HIV-1, whereas our monkey cousins are impervious to the virus? Part of the answer may lie with the virus' interaction with a cellular system of defense (pages 1138–1143).
引用
收藏
页码:1112 / 1113
页数:2
相关论文
共 8 条
  • [1] Restriction of lentivirus in monkeys
    Besnier, C
    Takeuchi, Y
    Towers, G
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (18) : 11920 - 11925
  • [2] Cyclophilin A is required for an early step in the life cycle of human immunodeficiency virus type 1 before the initiation of reverse transcription
    Braaten, D
    Franke, EK
    Luban, J
    [J]. JOURNAL OF VIROLOGY, 1996, 70 (06) : 3551 - 3560
  • [3] Cellular inhibitors with Fv1-like activity restrict human and simian immunodeficiency virus tropism
    Cowan, S
    Hatziioannou, T
    Cunningham, T
    Muesing, MA
    Gottlinger, HG
    Bieniasz, PD
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (18) : 11914 - 11919
  • [4] Operating under a gag order: A block against incoming virus by the Fv1 gene
    Goff, SP
    [J]. CELL, 1996, 86 (05) : 691 - 693
  • [5] HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 GAG PROTEIN BINDS TO CYCLOPHILIN-A AND CYCLOPHILIN-B
    LUBAN, J
    BOSSOLT, KL
    FRANKE, EK
    KALPANA, GV
    GOFF, SP
    [J]. CELL, 1993, 73 (06) : 1067 - 1078
  • [6] A dominant block to HIV-1 replication at reverse transcription in simian cells
    Münk, C
    Brandt, SM
    Lucero, G
    Landau, NR
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (21) : 13843 - 13848
  • [7] A conserved mechanism of retrovirus restriction in mammals
    Towers, G
    Bock, M
    Martin, S
    Takeuchi, Y
    Stoye, JP
    Danos, O
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (22) : 12295 - 12299
  • [8] Cyclophilin A modulates the sensitivity of HIV-1 to host restriction factors
    Towers, GJ
    Hatziioannou, T
    Cowan, S
    Goff, SP
    Luban, J
    Bieniasz, PD
    [J]. NATURE MEDICINE, 2003, 9 (09) : 1138 - 1143