Statistical model for diffusion attenuated MR signal

被引:204
作者
Yablonskiy, DA
Bretthorst, GL
Ackerman, JJH
机构
[1] Washington Univ, Sch Med, Dept Radiol, St Louis, MO 63110 USA
[2] Washington Univ, Dept Phys, St Louis, MO 63130 USA
[3] Washington Univ, Dept Chem, St Louis, MO 63130 USA
[4] Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USA
关键词
diffusion; magnetic resonance; MRI; MRS; CNS;
D O I
10.1002/mrm.10578
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
A general statistical model that can describe a rather large number of experimental results related to the structure of the diffusion-attenuated MR signal in biological systems is introduced. The theoretical framework relies on a phenomenological model that introduces a distribution function for tissue apparent diffusion coefficients (ADC). It is shown that at least two parameters-the position of distribution maxima (ADC) and the distribution width (sigma)-are needed to describe the MR signal in most regions of a human brain. A substantial distribution width on the order of 36% of the ADC, was found for practically all brain regions examined. This method of modeling the MR diffusion measurement allows determination of an intrinsic tissue specific ADC for a given diffusion time independent of the strength of diffusion sensitizing gradients. The model accounts for the previously found biexponential behavior of the diffusion-attenuated MR signal in CNS. (C) 2003 Wiley-Liss, Inc.
引用
收藏
页码:664 / 669
页数:6
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