Common malignancy-associated regions of transcriptional activation (MARTA) in human prostate, breast, ovarian, and colon cancers are targets for DNA amplification

被引：19

作者：

Glinsky, GV ^{[1
]}

Ivanova, YA ^{[1
]}

Glinskii, AB ^{[1
]}

机构：

[1] Sidney Kimmel Canc Ctr, San Diego, CA 92121 USA

来源：

CANCER LETTERS | 2003年 / 201卷 / 01期

关键词：

epithelial cancers; chromosomal domains; DNA amplification; expression profiling; microarray;

D O I：

10.1016/S0304-3835(03)00419-1

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Transcriptional co-regulation of sets of adjacent genes at the chromosomal domain level has been demonstrated recently in eukaryotes, supporting the idea that genomes are divided into regions of clustered expression of groups of adjacent genes. The mechanism underlying this phenomenon and its significance for human pathology is not yet known. Systematic analysis of the chromosomal positions of cancer-associated transcripts for prostate, breast, ovarian, and colon tumors identified short segments of human chromosomes that appear to represent a common target for transcriptional activation in major epithelial malignancies in human (1q21-q23 [140-160 Mbp]; 11q12-q13 [62-69 Mbp]; 12q13 [49-58 Mbp]; 17q21 [37-50 Mbp]; 17q23-q25 [70-81 Mbp]; 19p13 [0.2-19 Mbp]; Xq28 [147-153 Mbp]). At least some of these cancer-associated MARTAs correspond well to the regions of recurrent amplification in human cancer and seemed to be targets for DNA amplifications in established cancer cell lines. (C) 2003 Elsevier Ireland Ltd. All rights reserved.

引用

页码：67 / 77

页数：11

共 23 条

[1] A comprehensive, high-resolution genomic transcript map of human skeletal muscle [J].