Platelet ATP, Thyroid Hormone Receptor on Integrin αvβ3 and Cancer Metastasis

被引：29

作者：

Davis, Paul J. ^{[1
,2
,3
]}

Mousa, Shaker A. ^{[3
]}

Schechter, Geraldine P. ^{[4
,5
]}

Lin, Hung-Yun ^{[6
,7
,8
,9
]}

机构：

[1] Albany Med Coll, Dept Med, Albany, NY 12208 USA

[2] NanoPharmaceut LLC, Rensselaer, NY 12144 USA

[3] Albany Coll Pharm & Hlth Sci, Pharmaceut Res Inst, Rensselaer, NY 12144 USA

[4] Washington Vet Affairs Med Ctr, Med Serv, Hematol Sect, Washington, DC USA

[5] George Washington Univ, Dept Med, Washington, DC USA

[6] Taipei Med Univ, Canc Ctr, Taipei, Taiwan

[7] Taipei Med Univ, Coll Med Sci & Technol, Grad Inst Canc Mol Biol & Drug Discovery, Taipei, Taiwan

[8] Taipei Med Univ, Taipei Med Univ Hosp, Tradit Herbal Med Res Ctr, Taipei, Taiwan

[9] Taipei Med Univ, TMU Res Ctr Canc Translat Med, Taipei, Taiwan

来源：

HORMONES & CANCER | 2020年 / 11卷 / 01期

关键词：

3; 5; 3 '-Triiodo-L-thyronine (T3); Degranulation; Integrin; L-Thyroxine (T4); Metastasis; Thyroid hormone receptors; Tumor cell invasiveness; CELL-MIGRATION; RESISTANCE;

D O I：

10.1007/s12672-019-00371-4

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Activated platelets may contribute to the metastatic behavior of tumor cells when the cancer cells and platelets interact. The interaction requires cell and platelet surface integrin. Thyroid hormone as L-thyroxine (T4) is the principal ligand for a hormone receptor on integrin alpha v beta 3 on tumor cells and platelets. T4 activates the integrin, promoting platelet aggregation and degranulation (local ATP release) and stimulating tumor cell proliferation. By a variety of molecular mechanisms reviewed here, extracellular ATP promotes tumor cell invasiveness and metastasis and supports a role for T4 as a pro-metastatic factor.

引用

页码：13 / 16

页数：4

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