Natural killer cell trafficking in vivo requires a dedicated sphingosine 1-phosphate receptor

被引:331
作者
Walzer, Thierry
Chiossone, Laura
Chaix, Julie
Calver, Andrew
Carozzo, Claude
Garrigue-Antar, Laure
Jacques, Yannick
Baratin, Myriam
Tomasello, Elena
Vivier, Eric
机构
[1] Univ Mediterranee, Ctr Immunol Marseille Luminy, Inst Natl Sante & Rech Med, U631, F-13288 Marseille, France
[2] CNRS, UMR6102, F-13288 Marseille, France
[3] GlaxoSmithKline, New Frontiers Sci Pk, Harlow CM19 5AW, Essex, England
[4] Univ Lyon, UR RT12B, F-69003 Lyon, France
[5] Ecole Natl Vet, F-69280 Lyon, France
[6] Inst Natl Sante & Rech Med, Grp Rech Cytokines & Recepteurs, U601, Inst Biol, F-44093 Nantes, France
[7] Univ Nantes, Inst Biol, Unite Format & Rech Med, IFR26, F-44093 Nantes, France
[8] Hop Conception, Assistance Publ Hop Marseille, F-13005 Marseille, France
关键词
D O I
10.1038/ni1523
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Consistent with their function in immune surveillance, natural killer (NK) cells are distributed throughout lymphoid and nonlymphoid tissues. However, the mechanisms governing the steady-state trafficking of NK cells remain unknown. The lysophospholipid sphingosine 1-phosphate (S1P), by binding to its receptor S1P(1), regulates the recirculation of T and B lymphocytes. In contrast, S1P(5) is detected in the brain and regulates oligodendrocyte migration and survival in vitro. Here we show that S1P(5) was also expressed in NK cells in mice and humans and that S1P(5)- deficient mice had aberrant NK cell homing during steady-state conditions. In addition, we found that S1P(5) was required for the mobilization of NK cells to inflamed organs. Our data emphasize distinct mechanisms regulating the circulation of various lymphocyte subsets and raise the possibility that NK cell trafficking may be manipulated by therapies specifically targeting S1P(5).
引用
收藏
页码:1337 / 1344
页数:8
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