Accuracy limitations of chronaxie values

被引：77

作者：

Geddes, LA ^{[1
]}

机构：

[1] Purdue Univ, Dept Biomed Engn, W Lafayette, IN 47907 USA

来源：

IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING | 2004年 / 51卷 / 01期

关键词：

chronaxie; rheobase; stimulation; tissue excitability;

D O I：

10.1109/TBME.2003.820340

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The strength-duration curve is a plot of the threshold current (I) versus pulse duration (d) required to stimulate excitable tissue. On this curve are two points: 1) rheobase (b) and 2) chronaxie (c). Rheobase is the threshold current for an infinitely long-duration stimulus. Chronaxie, the excitability constant, is the duration of a pulse of current of twice rheobasic strength. The mathematical expression for the strength-duration curve is I = b(1 + c/d). Although there are many published values for chronaxie for various excitable tissues, the range of variability for a given tissue type is quite large. This paper identifies five factors that can affect the accuracy of chronaxie measurement and shows that the most reliable values can be obtained with a rectangular pulse delivered from a constant-current source.

引用

页码：176 / 181

页数：6

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