DNA variants of BAT-25 in Japanese, a locus frequently used for analysis of microsatellite instability

被引：8

作者：

Ichikawa, A ^{[1
]}

Sugano, K ^{[1
]}

Fujita, S ^{[1
]}

机构：

[1] Tochigi Canc Ctr, Res Inst, Oncogene Res Unit, Canc Prevent Unit, Utsunomiya, Tochigi 3200834, Japan

来源：

JAPANESE JOURNAL OF CLINICAL ONCOLOGY | 2001年 / 31卷 / 07期

关键词：

BAT-25; DNA variant; polymorphism; microsatellite instability; hereditary nonpolyposis colorectal cancer;

D O I：

10.1093/jjco/hye066

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

BAT-25 is a DNA marker, intragenic to the c-kit protooncogene, assigned to 4q12, containing a polythymine tract, mostly repeats of 25 poly(T) (T25). The BAT-25 locus is frequently used in the analysis of microsatellite instability (MSI) in cancer tissues. The number of poly(T) repeats at BAT-25 is reported to be quasi-monomorphic and this property permits the easy identification of the MSI status. We report DNA variants of BAT-25, in one patient with hereditary nonpolyposis colorectal cancer presenting T21 and T25 alleles and another carrying T18 and T25 alleles in the analysis of 100 normal Japanese donors. Observed allelic frequencies were 0.5% for both T21 and T18 alleles. So far, DNA variants of BAT-25 locus have been reported in African Americans with relatively high frequencies, but not in Japanese.

引用

页码：346 / 348

页数：3

共 11 条

[1] Incidence of hereditary nonpolyposis colorectal cancer and the feasibility of molecular screening for the disease
Aaltonen, LA
Salovaara, R
Kristo, P
Canzian, F
Hemminki, A
Peltomäki, P
Chadwick, RB
Kääriäinen, H
Eskelinen, M
Järvinen, H
Mecklin, JP
de la Chapelle, A
Percesepe, A
Ahtola, H
Härkönen, N
Julkunen, R
Kangas, E
Ojala, S
Tulikoura, J
ValKamo, E
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 1998, 338 (21) : 1481 - 1487
[2] Boland CR, 1998, CANCER RES, V58, P5248
[3] Association of tumour site and sex with survival benefit from adjuvant chemotherapy in colorectal cancer
Elsaleh, H
Joseph, D
Grieu, F
Zeps, N
Spry, N
Iacopetta, B
[J]. LANCET, 2000, 355 (9217) : 1745 - 1750
[4] UBIQUITOUS SOMATIC MUTATIONS IN SIMPLE REPEATED SEQUENCES REVEAL A NEW MECHANISM FOR COLONIC CARCINOGENESIS
IONOV, Y
PEINADO, MA
MALKHOSYAN, S
SHIBATA, D
PERUCHO, M
[J]. NATURE, 1993, 363 (6429) : 558 - 561
[5] Kane MF, 1997, CANCER RES, V57, P808
[6] Lynch HT, 1999, J MED GENET, V36, P801
[7] DNA methylation analysis using bisulfite treatment and PCR-single-strand conformation polymorphism in colorectal cancer showing microsatellite instability
Maekawa, M
Sugano, K
Kashiwabara, H
Ushiama, M
Fujita, S
Yoshimori, M
Kakizoe, T
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1999, 262 (03) : 671 - 676
[8] Enhanced detection of deleterious and other germline mutations of hMSH2 and hMLH1 in Japanese hereditary nonpolyposis colorectal cancer kindreds
Nomura, S
Sugano, K
Kashiwabara, H
Taniguchi, T
Fukayama, N
Fujita, S
Akasu, T
Moriya, Y
Ohhigashi, S
Kakizoe, T
Sekiya, T
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2000, 271 (01) : 120 - 129
[9] PARSONS R, 1995, CANCER RES, V55, P5548
[10] Polymorphic variation at the BAT-25 and BAT-26 loci in individuals of African origin - Implications for microsatellite instability testing
Pyatt, R
Chadwick, RB
Johnson, CK
Adebamowo, C
de la Chapelle, A
Prior, TW
[J]. AMERICAN JOURNAL OF PATHOLOGY, 1999, 155 (02) : 349 - 353

← 1 2 →