Polymerization of diaspirin crosslinked hemoglobin (DCLHb) with PEG activated with benzenesulfonate bearing electron-withdrawing groups

被引：5

作者：

Hai, TT ^{[1
]}

Pereira, DE ^{[1
]}

Nelson, DJ ^{[1
]}

Srnak, A ^{[1
]}

机构：

[1] Baxter Healthcare Corp, Hemoglobin Therapeut, Round Lake, IL 60073 USA

来源：

TETRAHEDRON | 1999年 / 55卷 / 08期

关键词：

proteins; polymerisation;

D O I：

10.1016/S0040-4020(98)01230-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The hemoglobin-based oxygen carrier solution. DCLHb, was polymerized with novel polyethylene glycol polymerization reagents to provide a solution of monomers to tetramers of hemoglobin molecules. The polyethylene glycol reagents 4 and 5 were designed to be selective toward nucleophilic displacement of the substituted benzenesulfonates by the sulfhydryl groups of beta 93 Cys of DCLHb. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：2147 / 2156

页数：10

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