Receptor binding, internalization, and retrograde transport of neurotrophic factors

被引：94

作者：

Neet, KE ^{[1
]}

Campenot, RB

机构：

[1] Finch Univ Hlth Sci Chicago Med Sch, Dept Biochem & Mol Biol, N Chicago, IL 60064 USA

[2] Univ Alberta, Dept Cell Biol, Edmonton, AB T6G 2H7, Canada

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2001年 / 58卷 / 08期

关键词：

neurotrophin; neurotrophic factor; nerve growth factor (NGF); glial cell-derived neurotrophic factor (GDNF); ciliary neurotrophic factor (CNTF); retrograde transport; receptor; Trk; cRet;

D O I：

10.1007/PL00000917

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This review deals with the receptor interactions of neurotrophic factors, focusing on the neurotrophins of the nerve growth factor (NGF) family, the glial cell derived neurotrophic factor (GDNF) family, and the ciliary neurotrophic factor (CNTF) family. The finding that two proteins, p75(NTR) and Trk, act as receptors for NGF in neurons generated the discovery of other neurotrophic factors/receptor families and has enhanced our understanding of the development, survival, regeneration, and degeneration of the nervous system. The kinetics of binding, the structure of the ligand-receptor complex, and the mechanism of retrograde transport of the neurotrophins are discussed in detail and compared to information available on the GDNF and CNTF families. Each neurotrophic factor family, i.e., NGF, GDNF, and CNTF, has a set of receptors with specificity for individual members of the family and a common receptor without member specificity that, in some families, generates the cellular signal and retrograde transport.

引用

页码：1021 / 1035

页数：15

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