Association of phosphodiesterase 4D gene with ischemic stroke in a Pakistani population

被引:101
作者
Saleheen, D
Bukhari, S
Haider, SR
Nazir, A
Khanum, S
Shafqat, S
Anis, K
Frossard, P
机构
[1] Aga Khan Univ, Coll Med, Dept Biol & Biomed Sci, Karachi, Pakistan
[2] Aga Khan Univ, Dept Med, Neurol Sect, Karachi, Pakistan
[3] Liaquat Natl Hosp, Karachi, Pakistan
[4] Aga Khan Univ, Dept Med, Gastroenterol Sect, Karachi, Pakistan
关键词
genetics; risk factors; stroke; ischemic;
D O I
10.1161/01.STR.0000182242.59466.ee
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background and Objectives-Identification of STRK1 locus by the deCODE group followed by the discovery of phosphodiesterase 4D ( PDE4D) gene in strong association with ischemic stroke patients has provided useful insights toward understanding the genetic etiology of the disease. In this study, we aimed at investigating the association between 3 polymorphisms of the PDE4D gene and ischemic stroke in the Pakistani population. Methods-Three polymorphisms in PDE4D gene were analyzed in 200 patients of ischemic stroke and 250 controls of Pakistani origin using polymerase chain reaction-restriction fragment length polymorphism method. Data were coded and entered in SPSS Windows ( version 12.0). Odds ratios and 95% CIs were calculated using multivariate logistic regression analysis. Results-Marker SNP83( rs966221) was found significantly associated with ischemic stroke on univariate and multivariate analysis ( P < 0.005; odds ratio, 1.64 [ 1.13 to 2.40]). Haplotype analysis for markers in linkage disequilibrium failed to show any association with the disease. Conclusion-The association of PDE4D variation with ischemic stroke extends to the Pakistani population and supports a role for phosphodiesterases in stroke pathogenesis.
引用
收藏
页码:2275 / 2277
页数:3
相关论文
共 10 条
[1]   Genetics of cerebrovascular disease [J].
Alberts, MJ .
STROKE, 2004, 35 (02) :342-344
[2]  
*AM HEART ASS, 2002, HEART DIS STROK STAT
[3]  
[Anonymous], ATL HEART DIS STROK
[4]   Analysis of the effects of phosphodiesterase type 3 and 4 inhibitors in cerebral arteries [J].
Birk, S ;
Edvinsson, L ;
Olesen, J ;
Kruuse, C .
EUROPEAN JOURNAL OF PHARMACOLOGY, 2004, 489 (1-2) :93-100
[5]  
BULATAO RA, 1992, GLOBAL ESTIMATES PRO, P1007
[6]   Sample size requirements for association studies of gene-gene interaction [J].
Gauderman, WJ .
AMERICAN JOURNAL OF EPIDEMIOLOGY, 2002, 155 (05) :478-484
[7]   The gene encoding phosphodiesterase 4D confers risk of ischemic stroke [J].
Gretarsdottir, S ;
Thorleifsson, G ;
Reynisdottir, ST ;
Manolescu, A ;
Jonsdottir, S ;
Jonsdottir, T ;
Gudmundsdottir, T ;
Bjarnadottir, SM ;
Einarsson, OB ;
Gudjonsdottir, HM ;
Hawkins, M ;
Gudmundsson, G ;
Gudmundsdottir, H ;
Andrason, H ;
Gudmundsdottir, AS ;
Sigurdardottir, M ;
Chou, TT ;
Nahmias, J ;
Goss, S ;
Sveinbjörnsdottir, S ;
Valdimarsson, EM ;
Jakobsson, F ;
Agnarsson, U ;
Gudnason, V ;
Thorgeirsson, G ;
Fingerle, J ;
Gurney, M ;
Gudbjartsson, D ;
Frigge, ML ;
Kong, A ;
Stefansson, K ;
Gulcher, JR .
NATURE GENETICS, 2003, 35 (02) :131-138
[8]   Localization of a susceptibility gene for common forms of stroke to 5q12 [J].
Gretarsdottir, S ;
Sveinbjörnsdottir, S ;
Jonsson, HH ;
Jakobsson, F ;
Einarsdottir, E ;
Agnarsson, U ;
Shkolny, D ;
Einarsson, G ;
Gudjonsdottir, HM ;
Valdimarsson, EM ;
Einarsson, OB ;
Thorgeirsson, G ;
Hadzic, R ;
Jonsdottir, S ;
Reynisdottir, ST ;
Bjarnadottir, SM ;
Gudmundsdottir, T ;
Gudlaugsdottir, GJ ;
Gill, R ;
Lindpaintner, K ;
Sainz, J ;
Hannesson, HH ;
Sigurdsson, GT ;
Frigge, ML ;
Kong, A ;
Gudnason, V ;
Stefansson, K ;
Gulcher, JR .
AMERICAN JOURNAL OF HUMAN GENETICS, 2002, 70 (03) :593-603
[9]   ALOX5AP gene and the PDE4D gene in a central European population of stroke patients [J].
Lohmussaar, E ;
Gschwendtner, A ;
Mueller, JC ;
Org, T ;
Wichmann, E ;
Hamann, G ;
Meitinger, T ;
Dichgans, M .
STROKE, 2005, 36 (04) :731-736
[10]  
Stoclet J.C., 1995, Exp. Opin. Invest. Drugs, V4, P1081, DOI DOI 10.1517/13543784.4.11.1081