Tuberomammillary nucleus lesion facilitates two-way active avoidance retention in rats

被引:20
作者
SeguraTorres, P
Wagner, U
MassanesRotger, E
AldavertVera, L
MartiNicolovius, M
MorgadoBernal, I
机构
[1] UNIV AUTONOMA BARCELONA,DEPT PSICOBIOL & METODOL CIENCIES SALUT,BELLATERRA 08193,BARCELONA,SPAIN
[2] UNIV DUSSELDORF,INST PHYSIOL PSYCHOL 1,D-4000 DUSSELDORF,GERMANY
关键词
tuberomammillary nucleus; lesion; two-way active avoidance; learning; memory;
D O I
10.1016/S0166-4328(97)81114-X
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
To evaluate whether the tuberomammillary nucleus might be involved in the acquisition and/or retention of a two-way active avoidance conditioning, rats were given a unilateral lesion of the tuberomammillary nucleus (E2 region) 24 h prior to the first conditioning session. Four learning sessions were performed: one acquisition and 3 retention sessions (short-term, 24 h; and longterm, 8 and 18 days). Results showed that the lesion facilitated the long-term retention of conditioning, but no effects were observed on acquisition and short-term retention. Since rewarding intracranial electrical stimulation seems to be a consistent way to facilitate learning and memory processes, and tuberomammillary lesion has been shown to improve intracranial self-stimulation behavior (ICSS), we suggest that lesions in the present experiment could have facilitated two-way active avoidance retention by enhancing the function of brain reward mechanisms.
引用
收藏
页码:113 / 117
页数:5
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