Effect of a microwave coagulator on implanted liver neoplasms in rats

被引:5
作者
Chen, HH
Cooper, A
Taylor, I
Johnson, CD
机构
[1] Univ Southampton, Southampton Gen Hosp, Surg Unit, Southampton SO16 6YD, Hants, England
[2] Third Hosp, Dept Surg, Beijing, Peoples R China
[3] Beijing Med Univ, Sch Clin Med, Beijing 100083, Peoples R China
[4] UCL, Dept Surg, London, England
关键词
liver tumours; liver metastases; microwave coagulation; rat;
D O I
10.1159/000018707
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
An experimental study was conducted to determine the applicability of a microwave (MW) source for coagulation and dissection of metastatic tumour and liver parenchyma, Twenty PVG rats were studied after implantation of MC28 tumour cells into the liver. Eleven days later they underwent sham laparotomy (control) MW coagulation of the tumour deposit, local resection of the tumour deposit with 2 mm clearance or resection of the tumour with MW coagulation of the resection zone. The control animals all died with blood-stained ascites and heavy tumour burden in the liver. After MW coagulation, tumours disappeared in all but one rat, Local resection also led to tumour clearance in 4 of 5 rats. MW coagulation of the resection zone allowed rapid bloodless resection, and no tumour recurrence was observed after 40-89 days. We conclude that MW coagulation is a potentially useful tool for ablation of hepatic metastasis and as an adjunct to hepatic resection.
引用
收藏
页码:140 / 144
页数:5
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