Biocompatibility of Calcined Mesoporous Silica Particles with Cellular Bioenergetics in Murine Tissues

被引：29

作者：

Al Shamsi, Mariam ^{[4
]}

Al Samri, Mohammed T. ^{[5
]}

Al-Salam, Suhail ^{[6
]}

Conca, Walter ^{[7
]}

Shaban, Sami ^{[8
]}

Benedict, Sheela ^{[5
]}

Tariq, Saeed ^{[9
]}

Biradar, Ankush V. ^{[1
,2
]}

Penefsky, Harvey S. ^{[3
]}

Asefa, Tewodros ^{[1
,2
]}

Souid, Abdul-Kader ^{[5
]}

机构：

[1] Rutgers State Univ, Dept Chem & Chem Biol, Piscataway, NJ 08854 USA

[2] Rutgers State Univ, Dept Chem Engn & Biochem Engn, Piscataway, NJ 08854 USA

[3] Publ Hlth Res Inst, Dept Biochem, Newark, NJ 07103 USA

[4] United Arab Emirates Univ, Fac Med & Hlth Sci, Dept Immunol, Abu Dhabi 17666, U Arab Emirates

[5] United Arab Emirates Univ, Fac Med & Hlth Sci, Dept Pediat, Abu Dhabi 17666, U Arab Emirates

[6] United Arab Emirates Univ, Fac Med & Hlth Sci, Dept Pathol, Abu Dhabi 17666, U Arab Emirates

[7] United Arab Emirates Univ, Fac Med & Hlth Sci, Dept Internal Med, Abu Dhabi 17666, U Arab Emirates

[8] United Arab Emirates Univ, Fac Med & Hlth Sci, Dept Med Educ, Abu Dhabi 17666, U Arab Emirates

[9] United Arab Emirates Univ, Fac Med & Hlth Sci, Dept Anat, Abu Dhabi 17666, U Arab Emirates

来源：

CHEMICAL RESEARCH IN TOXICOLOGY | 2010年 / 23卷 / 11期

基金：

美国国家科学基金会;

关键词：

AMORPHOUS SILICA; CRYSTALLINE SILICA; DRUG-DELIVERY; INHALATION TOXICITY; IN-VITRO; SURFACE; NANOPARTICLES; CYTOTOXICITY; RELEASE; NANOTECHNOLOGY;

D O I：

10.1021/tx100245j

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A novel in vitro system was developed to investigate the effects of two forms of calcined mesoporous silica particles (MCM41-cal and SBA15-cal) on cellular respiration of mouse tissues. O-2 consumption by lung, liver, kidney, spleen, and pancreatic tissues was unaffected by exposure to 200 mu g/mL MCM41-cal or SBA15-cal for several hours. Normal tissue histology was confirmed by light microscopy. Intracellular accumulation of the particles in the studied tissues was evident by electron microscopy. The results show reasonable in vitro biocompatibility of the mesoporous silicas with murine tissue bioenergetics.

引用

页码：1796 / 1805

页数：10

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