Effect of structural modification on the inhibitory selectivity of rutaecarpine derivatives on human CYP1A1, CYP1A2, and CYP1B1

被引：65

作者：

Don, MJ

Lewis, DFV

Wang, SY

Tsai, MW

Ueng, YF

机构：

[1] Natl Res Inst Chinese Med, Taipei 112, Taiwan

[2] Univ Surrey, Sch Biomed & Life Sci, Guildford GU2 7XH, Surrey, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 15期

关键词：

D O I：

10.1016/S0960-894X(03)00469-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

Derivatives of a CYP1A2 inhibitor rutaecarpine were synthesized to have potent and selective inhibition of human CYP1 members. Structural modelling shows a good fitting of rutaecarpine with the putative active site of human CYP1A2. Among the derivatives. 10- and 11-methoxyrutaecarpine are the most selective CYP1B1 inhibitors. 1-Methoxyrutaecarpine and 1,2-dimethoxyrutaecarpine are the most selective CYP1A2 inhibitors. (C) 2003 Elsevier Ltd. All rights reserved.

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页码：2535 / 2538

页数：4

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