Effect of tear secretory IgA on chemotaxis of polymorphonuclear leucocytes

被引：12

作者：

Lan, JX

Willcox, MDP

Jackson, GDF

Thakur, A

机构：

[1] Univ New S Wales, Cooperat Res Ctr Eye Res & Technol, Sydney, NSW, Australia

[2] Univ New S Wales, Cornea & Contact Lens Res Unit, Sydney, NSW, Australia

[3] Univ New S Wales, Sch Microbiol & Immunol, Sydney, NSW, Australia

来源：

AUSTRALIAN AND NEW ZEALAND JOURNAL OF OPHTHALMOLOGY | 1998年 / 26卷

关键词：

chemotaxis; polymorphonuclear leucocytes; secretory IgA;

D O I：

10.1111/j.1442-9071.1998.tb01367.x

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Purpose: The aim of-the present study was to examine the effect of tear and purified colostrum secretory IgA (sIgA) on polymorphonuclear leucocyte (PMN) chemo-taxis. Methods: The chemotactic effect of tear and purified sIgA for PMN was studied using a modified Boyden chamber. Tears treated with anti-human IgA, complement-inactivated tears and albumin were used as controls. Results: The data indicate that both tear and purified sIgA are highly chemotactic for PMN. Anti-sIgA antibodies reduced the chemotactic effect of closed-eye tears (34%) and tear collected during ocular inflammation. Conclusion: The massive recruitment of PMN in tears during sleep may be partially attributed to the increased levels of tear sIgA. This may play an important role in protecting the eye against bacterial infection.

引用

页码：S36 / S39

页数：4

共 11 条

[1] EFFECTS OF RECOMBINANT GM-CSF AND IGA OPSONIZATION ON NEUTROPHIL PHAGOCYTOSIS OF LATEX BEADS COATED WITH P6 OUTER-MEMBRANE PROTEIN FROM HAEMOPHILUS-INFLUENZAE [J].