Cutting edge:: CD28 controls peripheral homeostasis of CD4+CD25+

被引：551

作者：

Tang, QZ

Henriksen, KJ

Boden, EK

Tooley, AJ

Ye, JQ

Subudhi, SK

Zheng, XX

Strom, TB

Bluestone, JA

机构：

[1] Univ Calif San Francisco, Ctr Diabet, San Francisco, CA 94143 USA

[2] Univ Chicago, Comm Immunol, Chicago, IL 60637 USA

[3] Harvard Univ, Beth Israel Deaconess Med Ctr, Dept Med, Div Immunol, Boston, MA 02215 USA

来源：

JOURNAL OF IMMUNOLOGY | 2003年 / 171卷 / 07期

关键词：

REGULATORY T-CELLS; IMMUNOLOGICAL SELF-TOLERANCE; AUTOIMMUNITY; MICE; RECEPTOR; GENE; EXPRESSION; MEMORY; IL-2;

D O I：

10.4049/jimmunol.171.7.3348

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

CD28/B7 blockade leads to exacerbated autoimmune disease in the nonobese diabetic mouse strain as a result of a marked reduction in the number of CD4(+) CD25(+) regulatory T cells (Tregs). Herein, we demonstrate that CD28 controls both thymic development and peripheral homeostasis of Tregs. CD28 maintains a stable pool of peripheral Tregs by both supporting their survival and promoting their self-renewal. CD28 engagement promotes survival by regulating IL-2 production by conventional T cells and CD25 expression on Tregs.

引用

收藏

页码：3348 / 3352

页数：5

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