Glucagon as a Critical Factor in the Pathology of Diabetes

被引:42
作者
Edgerton, Dale S. [1 ]
Cherrington, Alan D. [1 ]
机构
[1] Vanderbilt Univ, Sch Med, Dept Mol Physiol & Biophys, Nashville, TN 37212 USA
关键词
HEPATIC GLUCOSE-PRODUCTION; POSTPRANDIAL HYPERGLYCEMIA; INSULIN-RESISTANCE; METABOLISM; GLP-1; DISPOSAL; RECEPTOR; MICE; SUPPRESSION; DEFICIENCY;
D O I
10.2337/db10-1594
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:377 / 380
页数:4
相关论文
共 35 条
[1]   Benefits and limitations of reducing glucagon action for the treatment of type 2 diabetes [J].
Ali, Safina ;
Drucker, Daniel J. .
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2009, 296 (03) :E415-E421
[2]   Effects of free fatty acids (FFA) on glucose metabolism: Significance for insulin resistance and type 2 diabetes [J].
Boden, G .
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES, 2003, 111 (03) :121-124
[3]   GLUCAGON DEFICIENCY AND HYPERAMINOACIDEMIA AFTER TOTAL PANCREATECTOMY [J].
BODEN, G ;
MASTER, RW ;
REZVANI, I ;
PALMER, JP ;
LOBE, TE ;
OWEN, OE .
JOURNAL OF CLINICAL INVESTIGATION, 1980, 65 (03) :706-716
[4]   A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance [J].
Bruning, JC ;
Michael, MD ;
Winnay, JN ;
Hayashi, T ;
Horsch, D ;
Accili, D ;
Goodyear, LJ ;
Kahn, CR .
MOLECULAR CELL, 1998, 2 (05) :559-569
[5]   REGULATION OF FREE FATTY-ACID METABOLISM BY GLUCAGON [J].
CARLSON, MG ;
SNEAD, WL ;
CAMPBELL, PJ .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1993, 77 (01) :11-15
[6]   Use of GLUT-4 null mice to study skeletal muscle glucose uptake [J].
Charron, MJ ;
Gorovits, N ;
Laidlaw, JS ;
Ranalletta, M ;
Katz, EB .
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2005, 32 (04) :308-313
[7]   Glucagon chronically impairs hepatic and muscle glucose disposal [J].
Chen, Sheng-Song ;
Zhang, Yiqun ;
Santomango, Tammy S. ;
Williams, Phillip E. ;
Lacy, D. Brooks ;
McGuinness, Owen P. .
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2007, 292 (03) :E928-E935
[8]   Glucagon-mediated impairments in hepatic and peripheral tissue nutrient disposal are not aggravated by increased lipid availability [J].
Chen, Sheng-Song ;
Santomango, Tammy S. ;
Williams, Phillip E. ;
Lacy, D. Brooks ;
McGuinness, Owen P. .
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2009, 296 (05) :E1172-E1178
[9]   EFFECT OF GLUCAGON ON GLUCOSE PRODUCTION DURING INSULIN DEFICIENCY IN DOG [J].
CHERRINGTON, AD ;
LACY, WW ;
CHIASSON, JL .
JOURNAL OF CLINICAL INVESTIGATION, 1978, 62 (03) :664-677
[10]   Glucagon receptor knockout mice are resistant to diet-induced obesity and streptozotocin-mediated beta cell loss and hyperglycaemia [J].
Conarello, S. L. ;
Jiang, G. ;
Mu, J. ;
Li, Z. ;
Woods, J. ;
Zycband, E. ;
Ronan, J. ;
Liu, F. ;
Roy, R. Sinha ;
Zhu, L. ;
Charron, M. J. ;
Zhang, B. B. .
DIABETOLOGIA, 2007, 50 (01) :142-150