Mesoporous silicon: a platform for the delivery of therapeutics

被引：101

作者：

Prestidge, Clive A. ^{[2
]}

Barnes, Timothy J. ^{[2
]}

Lau, Chi-Hian ^{[1
]}

Barnett, Christian ^{[1
]}

Loni, Armando ^{[1
]}

Canham, Leigh ^{[1
]}

机构：

[1] PSIMedica Ltd, CSO, Malvern WR14 3SZ, Worcs, England

[2] Univ S Australia, Ian Wark Res Inst, Adelaide, SA 5001, Australia

来源：

EXPERT OPINION ON DRUG DELIVERY | 2007年 / 4卷 / 02期

基金：

澳大利亚研究理事会;

关键词：

drug delivery; nanostructuring; porous silicon; WATER-SOLUBLE DRUGS; HUMAN SERUM-ALBUMIN; POROUS SILICON; DISSOLUTION; ACID; FORMULATION; FABRICATION; PARTICLES; CHEMISTRY; GERMANIUM;

D O I：

10.1517/17425247.4.2.101

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Nanostructuring materials can radically change their proper-ties. Two interesting examples highlighted here are nanoscale porosity inducing biodegradability, and nanoscale confinement affecting the physical form of an entrapped drug. Mesoporous silicon is under increasing study for drug-delivery applications, and is the topic of this review. The authors focus on those proper-ties of most relevance to this application, as well as those recent studies published on small molecule and peptide/protein delivery.

引用

页码：101 / 110

页数：10

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