Circulating beta amyloid protein is elevated in patients with acute ischemic stroke

Recent clinical and experimental studies suggest that ischemic strokes may play an important role in the pathogenesis of Alzheimer's disease ( AD). Beta amyloid ( Ab), a major component of senile plaque in AD, is known to be derived from ischemic brain or activated platelets. We prospectively enrolled 62 patients with acute ischemic stroke and 27 age-matched controls. The serum Ab and P-selectin levels were determined using the Sandwich-ELISA. We divided ischemic strokes into subgroups according to the clinical syndrome, pathogenesis, and infarct size, and compared the Ab level between each subgroup. The A beta 1-40 level was markedly elevated in ischemic stroke patients, as compared to controls (140.2 +/- 54.0 vs 88.44 +/- 34.96 pg= ml, p< 0.001). Cardioembolic and larger artery atherosclerotic infarcts had higher A beta 1-40 level than small vessel disease (p= 0.001). Both infarct size and the initial NIHSS score had significantly positive correlations with the serum level of A beta 1-40 ( r = 0.539, p< 0.001 and r = 0.425, p = 0.001, respectively). However, the P-selectin level was not significantly correlated with serum A beta 1-40. Our data suggest that elevated circulating A beta 1-40 in ischemic stroke.