Diet in the aetiology of ulcerative colitis:: A European prospective cohort study

被引：112

作者：

Hart, Andrew R. ^{[1
,12
]}

Luben, Robert ^{[1
]}

Olsen, Anja ^{[2
]}

Tjonneland, Anne ^{[2
]}

Linseisen, Jakob ^{[3
]}

Nagel, Gabriele ^{[3
]}

Berglund, Goeran ^{[4
]}

Lindgren, Stefan ^{[4
]}

Grip, Olof ^{[4
]}

Key, Timothy ^{[5
]}

Appleby, Paul ^{[5
]}

Bergmann, Manuela M. ^{[6
]}

Boeing, Heiner ^{[6
]}

Hallmans, Goeran ^{[7
,8
]}

Danielsson, Ake ^{[7
,8
]}

Palmqvist, Richard ^{[7
,8
]}

Sjodin, Hubert ^{[7
,8
]}

Hagglund, Gun ^{[7
,8
]}

Overvad, Kim ^{[9
]}

Palli, Domenico ^{[10
]}

Masala, Giovanna ^{[10
]}

Riboli, Elio ^{[11
]}

Kennedy, Hugh ^{[12
]}

Welch, Ailsa ^{[1
]}

Khaw, Kay-Tee ^{[1
]}

Day, Nicholas ^{[1
]}

Bingham, Sheila ^{[1
]}

机构：

[1] Univ Cambridge, Inst Publ Hlth, Strangeways Res Lab, Cambridge, England

[2] Danish Canc Soc, Inst Canc Epidemiol, Copenhagen, Denmark

[3] DKFZ German Canc Res Ctr, Div Clin Epidemiol, Heidelberg, Germany

[4] Univ Hosp, Dept Clin Sci, Malmo, Sweden

[5] Univ Oxford, Canc Res UK Epidemiol Unit, Oxford, England

[6] German Inst Human Nutr, Dept Epidemiol, Potsdam, Germany

[7] Umea Univ, Dept Med, GI Unit, S-90187 Umea, Sweden

[8] Umea Univ, Dept Nutr Res & Med Biosci, S-90187 Umea, Sweden

[9] Univ Aarhus, Dept Clin Epidemiol, Aarhus, Denmark

[10] Canc Res & Prevent Ctr, Mol & Nutr Epidemiol Unit, Florence, Italy

[11] Univ London Imperial Coll Sci Technol & Med, Div Epidemiol, London, England

[12] Norfolk & Norwich Hosp, NHS Trust, Norwich NR1 3SR, Norfolk, England

来源：

DIGESTION | 2008年 / 77卷 / 01期

基金：

英国医学研究理事会;

关键词：

ulcerative colitis; aetiology; diet; polyunsaturated fatty acids;

D O I：

10.1159/000121412

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background/Aims: The causes of ulcerative colitis are unknown, although it is plausible that dietary factors are involved. Case-control studies of diet and ulcerative colitis are subject to recall biases. The aim of this study was to examine the prospective relationship between the intake of nutrients and the development of ulcerative colitis in a cohort study. Methods: The study population was 260,686 men and women aged 20-80 years, participating in a large European prospective cohort study (EPIC). Participants were residents in the UK, Sweden, Denmark, Germany or Italy. Information on diet was supplied and the subjects were followed up for the development of ulcerative colitis. Each incident case was matched with four controls and dietary variables were divided into quartiles. Results: A total of 139 subjects with incident ulcerative colitis were identified. No dietary associations were detected, apart from a marginally significant positive association with an increasing percentage intake of energy from total polyunsaturated fatty acids (trend across quartiles OR = 1.19 (95% CI = 0.99-1.43) p = 0.07). Conclusions: No associations between ulcerative colitis and diet were detected, apart from a possible increased risk with a higher total polyunsaturated fatty acid intake. A biological mechanism exists in that polyunsaturated fatty acids are metabolised to pro-inflammatory mediators.

引用

页码：57 / 64

页数：8

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