Preparation and characterization of porous hollow silica nanoparticles for drug delivery application

被引：465

作者：

Chen, JF ^{[1
]}

Ding, HM ^{[1
]}

Wang, JX ^{[1
]}

Shao, L ^{[1
]}

机构：

[1] Beijing Univ Chem Technol, Coll Chem Engn, Res Ctr, Minist Educ High Grav Engn & Technol, Beijing 100029, Peoples R China

来源：

BIOMATERIALS | 2004年 / 25卷 / 04期

基金：

中国国家自然科学基金;

关键词：

porous hollow silica nanoparticles; nanosized calcium carbonate; cefradine; drug release;

D O I：

10.1016/S0142-9612(03)00566-0

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Porous hollow silica nanoparticles (PHSNP) with a diameter of 60-70 nm and wall thickness of approximately 10 nm were synthesized by using CaCO3 nano-particles as the inorganic template. The characterization of PHSNP by TEM and BET indicated that PHSNP were uniform spherical particles with good dispersion, and had a specific surface area of 867 m(2)/g. The as-synthesized PHSNP were subsequently employed as drug carrier to investigate in vitro release behavior of cefradine in simulated body fluid. UV-spectrometry and TG analyses were performed to determine the amount of cefradine entrapped in the carrier. The BJH pore size distribution of PHSNP before and after entrapping cefradine was examined. Cefradine release profile from PHSNP followed a three-stage pattern and exhibited a delayed release effect. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：723 / 727

页数：5

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