Adjuvant chemotherapy in elderly patients with breast cancer: a survey of the Breast International Group (BIG)

被引：45

作者：

Biganzoli, L

Goldhirsch, A

Straehle, C

Castiglione-Gertsch, M

Therasse, P

Aapro, M

Minisini, A

Piccart, MJ

机构：

[1] Inst Jules Bordet, B-1000 Brussels, Belgium

[2] European Inst Oncol, Milan, Italy

[3] BIG Secretariat, Brussels, Belgium

[4] IBCSG Coordinating Ctr, Bern, Switzerland

[5] Eortc Data Ctr, Brussels, Belgium

[6] EORTC, IDBBC, Brussels, Belgium

来源：

ANNALS OF ONCOLOGY | 2004年 / 15卷 / 02期

关键词：

adjuvant chemotherapy; breast cancer; elderly; geriatric oncology; survey;

D O I：

10.1093/annonc/mdh062

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: To collect oncologists' experience and opinion on adjuvant chemotherapy in elderly breast cancer patients. Materials and methods: A questionnaire was circulated among the members of the Breast International Group. Results: A total of 277 oncologists from 28 countries participated in the survey. Seventy years is the age cutoff commonly used to define a patient as elderly. Biological age and the biological characteristics of the tumor are the most frequently used criteria to propose adjuvant chemotherapy to an elderly patient. Combination therapy with cyclophosphamide, methotrexate and fluorouracil on days I and 8 is the most frequently prescribed regimen. Great interest exists in oral chemotherapy. Conclusion: There is interest among those who responded to the survey to validate a comprehensive geriatric assessment for use as a predictive instrument of toxicity and/or activity of anticancer therapy and to evaluate the role of a treatment option that is potentially less toxic and possibly as effective as polychemotherapy.

引用

页码：207 / 210

页数：4

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