TLR signaling pathways

被引：1965

作者：

Takeda, K

Akira, S

机构：

[1] Osaka Univ, Dept Host Def, Microbial Dis Res Inst, Suita, Osaka 5650871, Japan

[2] Japan Sci & Technol Corp, ERATO, Suita, Osaka 5650871, Japan

来源：

SEMINARS IN IMMUNOLOGY | 2004年 / 16卷 / 01期

关键词：

TLR; innate immunity; signal transduction; TIR domain;

D O I：

10.1016/j.smim.2003.10.003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Toll-like receptors (TLRs) have been established to play an essential role in the activation of innate immunity by recognizing specific patterns of microbial components. TLR signaling pathways arise from intracytoplasmic TIR domains, which are conserved among all TLRs. Recent accumulating evidence has demonstrated that TIR domain-containing adaptors, such as MyD88, TIRAP, and TRIF, modulate TLR signaling pathways. MyD88 is essential for the induction of inflammatory cytokines triggered by all TLRs. TIRAP is specifically involved in the MyD88-dependent pathway via TLR2 and TLR4, whereas TRIF is implicated in the TLR3- and TLR4-mediated MyD88-independent pathway. Thus, TIR domain-containing adaptors provide specificity of TLR signaling. (C) 2003 Elsevier Ltd. All rights reserved.

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页码：3 / 9

页数：7

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