Bone morphogenetic protein 7 (BMP7): A critical role in kidney development and a putative modulator of kidney injury

被引：56

作者：

Archdeacon, Patrick ^{[1
]}

Detwiler, Randal K. ^{[1
]}

机构：

[1] Univ N Carolina, Kidney Ctr, UNC Hosp, Div Nephrol & Hypertens, Chapel Hill, NC 27599 USA

来源：

ADVANCES IN CHRONIC KIDNEY DISEASE | 2008年 / 15卷 / 03期

关键词：

bone morphogenetic protein 7; epithelial-to-mesenchymal transformation; interstitial fibrosis; tumor growth factor beta; type I activin receptor-like kinase;

D O I：

10.1053/j.ackd.2008.04.011

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Bone morphogenetic protein 7 (BMP7), a member of the tumor growth factor beta superfamily, appears to have a role in both kidney development and response to kidney injury. Signals through its pathways permit both epithelial differentiation during embryogenesis and preservation of normal kidney architecture after stress, leading to the hypothesis that BMP7 may exert its kidney-protective effects in adult animals by preventing or reversing epithelial-to-mesenchymal transformation. This review attempts to synthesize the data supporting those conclusions and suggest some future areas of research. (C) 2008 by the National Kidney Foundation, Inc. All rights reserved.

引用

页码：314 / 320

页数：7

共 36 条

[1]

Characterization of receptors for osteogenic protein-1/bone morphogenetic protein-7 (OP-1/BMP-7) in rat kidneys [J].

Bosukonda, D ;

Shih, MS ;

Sampath, KT ;

Vukicevic, S .

KIDNEY INTERNATIONAL, 2000, 58 (05) :1902-1911

[2]

A REQUIREMENT FOR BONE MORPHOGENETIC PROTEIN-7 DURING DEVELOPMENT OF THE MAMMALIAN KIDNEY AND EYE [J].

DUDLEY, AT ;

LYONS, KM ;

ROBERTSON, EJ .

GENES & DEVELOPMENT, 1995, 9 (22) :2795-2807

[3]

Transforming growth factor-β regulates tubular epithelial-myofibroblast transdifferentiation in vitro [J].

Fan, JM ;

Ng, YY ;

Hill, PA ;

Nikolic-Paterson, DJ ;

Mu, W ;

Atkins, RC ;

Lan, HY .

KIDNEY INTERNATIONAL, 1999, 56 (04) :1455-1467

[4]

Friedlaender GE, 2001, J BONE JOINT SURG AM, V83A, pS151

[5]

BMP-7 regulates chemokine, cytokine, and hemodynamic gene expression in proximal tubule cells [J].

Gould, SE ;

Day, M ;

Jones, SS ;

Dorai, H .

KIDNEY INTERNATIONAL, 2002, 61 (01) :51-60

[6]

Gu ZY, 1999, DEVELOPMENT, V126, P2551

[7]

Osteogenic protein-1 prevents renal fibrogenesis associated with ureteral obstruction [J].

Hruska, KA ;

Guo, GJ ;

Wozniak, M ;

Martin, D ;

Miller, S ;

Liapis, H ;

Loveday, K ;

Klahr, S ;

Sampath, TK ;

Morrissey, J .

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2000, 279 (01) :F130-F143

[8]

The formation of bone under the influence of epithelium of the urinary tract [J].

Huggins, CB .

ARCHIVES OF SURGERY, 1931, 22 (03) :377-408

[9]

Evidence that fibroblasts derive from epithelium during tissue fibrosis [J].

Iwano, M ;

Plieth, D ;

Danoff, TM ;

Xue, C ;

Okada, H ;

Neilson, EG .

JOURNAL OF CLINICAL INVESTIGATION, 2002, 110 (03) :341-350

[10]

INTERACTION OF MUTANT IPR GENE WITH BACKGROUND STRAIN INFLUENCES RENAL-DISEASE [J].

KELLEY, VE ;

ROTHS, JB .

CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY, 1985, 37 (02) :220-229

← 1 2 3 4 →