Synthesis of a series of sulfinic acid analogs of GABA and evaluation of their GABAA receptor affinities

被引：12

作者：

Carruthers, NI

Spitler, JM

Wong, SC

Blythin, DJ

Chen, X

Shue, HJ

She, HS

Lee, JF

Rizzo, C

Ting, PC

West, RE

机构：

[1] Schering Plough Corp, Res Inst, Dept Chem Res, Kenilworth, NJ 07033 USA

[2] Schering Plough Corp, Res Inst, Dept Allergy & Immunol, Kenilworth, NJ 07033 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 21期

关键词：

D O I：

10.1016/S0960-894X(98)00565-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of gamma-aminobutyric acid (GABA) I analogs was prepared in which the carboxylic acid group of GABA was replaced with a sulfinic acid group and their affinity for the GABAB receptor investigated. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

收藏

页码：3059 / 3064

页数：6

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