Synthesis and cellular uptake of cell delivering PNA-peptide conjugates

被引：19

作者：

Díaz-Mochón, JJ ^{[1
]}

Bialy, L ^{[1
]}

Watson, J ^{[1
]}

Sánchez-Martín, RM ^{[1
]}

Bradley, M ^{[1
]}

机构：

[1] Univ Edinburgh, Sch Chem, Edinburgh EH9 3JJ, Midlothian, Scotland

来源：

CHEMICAL COMMUNICATIONS | 2005年 / 26期

基金：

英国生物技术与生命科学研究理事会;

关键词：

D O I：

10.1039/b503777h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The synthesis and cellular uptake of fluorescently labelled PNA-peptide conjugates is described; Dde/Mmt protected PNA monomers, fully orthogonal to Fmoc chemistry, were used to develop a flexible strategy to give Peptide Nucleic Acids conjugated to tri- and hepta-arginine and the short basic Tat(48-57) peptide as examples of cellular penetrating peptides, thereby allowing efficient cellular delivery of PNA into cells.

引用

页码：3316 / 3318

页数：3

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