To bind or note to bind

被引:16
作者
Biggin, MD [1 ]
机构
[1] Univ Calif Berkeley, Lawrence Berkeley Lab, Genome Sci Dept, Berkeley, CA 94720 USA
关键词
D O I
10.1038/91045
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Gene expression is regulated by transcription factors binding selectively to particular portions of the genome. To what extent are these protein-DNA interactions influenced by the intrinsic sequence-specific recognition properties at each protein, and to what extent are they affected by other factors, such as chromatin structure or cooperative interactions with other proteins. Genome-wide surveys of DNA binding by transcription factors in vivo are beginning to provide some answers.
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页码:303 / 304
页数:2
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