Isolation of multipotent adult stem cells from the dermis of mammalian skin

被引：1249

作者：

Toma, JG

Akhavan, M

Fernandes, KJL

Barnabé-Heider, F

Sadikot, A

Kaplan, DR

Miller, FD

机构：

[1] McGill Univ, Montreal Neurol Inst, Ctr Neuronal Survival, Montreal, PQ H3A 2B4, Canada

[2] McGill Univ, Montreal Neurol Inst, Brain Tumor Res Ctr, Montreal, PQ H3A 2B4, Canada

[3] McGill Univ, Montreal Neurol Inst, Div Neurosurg, Montreal, PQ H3A 2B4, Canada

来源：

NATURE CELL BIOLOGY | 2001年 / 3卷 / 09期

基金：

加拿大自然科学与工程研究理事会; 加拿大健康研究院;

关键词：

D O I：

10.1038/ncb0901-778

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 [细胞生物学]; 090102 [作物遗传育种];

摘要：

We describe here the isolation of stem cells from juvenile and adult rodent skin. These cells derive from the dermis, and clones of individual cells can proliferate and differentiate in culture to produce neurons, glia, smooth muscle cells and adipocytes. Similar precursors that produce neuron-specific proteins upon differentiation can be isolated from adult human scalp. Because these cells (termed SKPs for skin-derived precursors) generate both neural and mesodermal progeny, we propose that they represent a novel multipotent adult stem cell and suggest that skin may provide an accessible, autologous source of stem cells for transplantation.

引用

页码：778 / 784

页数：7

共 33 条

[1]

Engraftment and migration of human bone marrow stromal cells implanted in the brains of albino rats - similarities to astrocyte grafts [J].