Immunomodulatory principles of Dichrocephala bicolor

被引：60

作者：

Lin, LC ^{[1
]}

Kuo, YC ^{[1
]}

Chou, CJ ^{[1
]}

机构：

[1] Natl Res Inst Chinese Med, Taipei 11221, Taiwan

来源：

JOURNAL OF NATURAL PRODUCTS | 1999年 / 62卷 / 03期

关键词：

D O I：

10.1021/np980153o

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

From the ethanolic extract of Dichrocephala bicolor eight compounds-4,5-dicaffeoyl quinic acid (1); 3,4-dicaffeoyl quinic acid (2); 3,5-dicaffeoyl quinic acid (3); ethyl 4,5-dicaffeoyl quinate (4); methyl 3,5-dicaffeoyl quinate (5); 5-caffeoyl quinic acid (6); caffeic acid (7); and quercetin-3-O-rutinoside (8)-were isolated and identified. All of them were selected for immunopharmacological activity tesing. Human mononuclear cells (HMNC) were used as target cells. Cell proliferation was determined by H-3-thymidine uptake. Compounds 2 and 6 potently enhanced HMNC proliferation and interferon-gamma production. Enhancement mechanisms may involve the increase of cytokines production.

引用

页码：405 / 408

页数：4

共 11 条

[1] CYTOKINES - COORDINATORS OF IMMUNE AND INFLAMMATORY RESPONSES [J].