The interferon response circuit: Induction and suppression by pathogenic viruses

被引：530

作者：

Haller, O ^{[1
]}

Kochs, G ^{[1
]}

Weber, F ^{[1
]}

机构：

[1] Univ Freiburg, Abt Virol, Inst Med Mikrobiol & Hyg, D-79008 Freiburg, Germany

来源：

VIROLOGY | 2006年 / 344卷 / 01期

关键词：

D O I：

10.1016/j.virol.2005.09.024

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Type I interferons (IFN-alpha/beta) are potent antiviral cytokines and modulators of the adaptive immune system. They are induced by viral infection or by double-stranded RNA (dsRNA), a by-product of viral replication, and lead to the production of a broad range of antiviral proteins and immunoactive cytokines. Viruses, in turn, have evolved multiple strategies to counter the IFN system which would otherwise stop virus growth early in infection. Here we discuss the current view on the balancing act between virus-induced IFN responses and the viral counterplayers. (c) 2005 Elsevier Inc. All rights reserved.

引用

页码：119 / 130

页数：12

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