Biotransformation of a 4α-hydroxylated eudesmane with Exserohilum halodes -: Chemo-enzymatic synthesis of cryptomeridiol and 6-epi-colartin derivatives

被引：8

作者：

García-Granados, A ^{[1
]}

Gutiérrez, MC ^{[1
]}

Rivas, F ^{[1
]}

机构：

[1] Univ Granada, Fac Ciencias, Dept Quim Organ, E-18071 Granada, Spain

来源：

JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC | 2004年 / 27卷 / 2-3期

关键词：

whole-cell biotransformation; microbial hydroxylation; sesquiterpene lactones; Exserohilum halodes;

D O I：

10.1016/j.molcatb.2003.10.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Microbial transformation of a 4alpha-hydroxylated eudesmane by Exserohilum halodes has been achieved. Regioselective hydroxylations in both "A" and "B" rings, on C-2 and C-8, were detected, but the main hydroxylating action was directed to the isopropyl moiety and cryptomeridiol analogues were isolated. Semi-synthesis of two sesquiterpenolides, 6-epi-colartin derivatives, were accomplished from the significant metabolites hydroxylated at C-12. (C) 2003 Elsevier B.V. All rights reserved.

引用

页码：133 / 138

页数：6

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