The Alzheimer's β amyloid (Aβ1-39) monomer in an implicit solvent

被引：22

作者：

Anand, Priya ^{[1
,2
]}

Nandel, F. S. ^{[2
]}

Hansmann, Ulrich H. E. ^{[1
,3
]}

机构：

[1] Forschungszentrum Julich, John von Neumann Inst Computing, D-52425 Julich, Germany

[2] Panjab Univ, Dept Biophys, Chandigarh 160014, India

[3] Michigan Technol Univ, Dept Phys, Houghton, MI 49931 USA

来源：

JOURNAL OF CHEMICAL PHYSICS | 2008年 / 128卷 / 16期

关键词：

D O I：

10.1063/1.2907718

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Results from replica-exchange and regular room temperature molecular dynamics simulations of the Alzheimer's beta amyloid (A beta(1-39)) monomer in an implicit solvent are reported. Our data indicate that at room temperature, the monomer assumes random-coil and soluble conformations. No beta content is observed which therefore seems to be a product of oligomerization and aggregation of monomers. (c) 2008 American Institute of Physics.

引用

页数：5

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