Immunology in the Clinic Review Series; focus on metabolic diseases: development of islet autoimmune disease in type 2 diabetes patients: potential sequelae of chronic inflammation

被引：70

作者：

Brooks-Worrell, B. ^{[1
,2
]}

Palmer, J. P. ^{[1
,2
]}

机构：

[1] Univ Washington, Dept Med, Seattle, WA USA

[2] VA Med Ctr, Seattle, WA USA

来源：

CLINICAL AND EXPERIMENTAL IMMUNOLOGY | 2012年 / 167卷 / 01期

关键词：

autoimmunity; diabetes; inflammation; inflammatory mediators including eicosanoids; T cells; REGULATORY T-CELLS; INSULIN-RECEPTOR SUBSTRATE-1; ADIPOSE-TISSUE INFLAMMATION; BODY-MASS INDEX; HUMORAL AUTOIMMUNITY; WAIST CIRCUMFERENCE; SIGNAL-TRANSDUCTION; BETA-CELL; OBESITY; RESISTANCE;

D O I：

10.1111/j.1365-2249.2011.04501.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Historically, the development of type 2 diabetes has been considered not to have an autoimmune component, in contrast to the autoimmune pathogenesis of type 1 diabetes. In this review we will discuss the accumulating data supporting the concept that islet autoreactivity and inflammation is present in type 2 diabetes pathogenesis, and the islet autoimmunity appears to be one of the factors associated with the progressive nature of the type 2 diabetes disease process.

引用

页码：40 / 46

页数：7

共 79 条

[1]

Abraham A, 2011, DIABETES, V60, pA43

[2]

SYNGENEIC TRANSFER OF AUTOIMMUNE DIABETES FROM DIABETIC NOD MICE TO HEALTHY NEONATES - REQUIREMENT FOR BOTH L3T4+ AND LYT-2+ T-CELLS [J].